That's how I carry my 3" 1911 when I go concealed, using a holster that carries it straight up and down. I've found it gives you the best access while seated in a car seat (especially something with side bolsters), and though you feel it when leaning forward, you don't print like you would at 4:00.
That said, I'm glad it's something with a manual safety.. just for that added bit of protection.